Research directory

Clinical trials for IBD

Below are clinical trials currently recruiting participants in the United States.

125 studies

Long-term tulisokibart extension study for Crohn’s disease or ulcerative colitis

A long-term extension study of tulisokibart for people with Crohn’s disease or ulcerative colitis who participated in certain parent studies.

Colitis, Ulcerative · Crohn Disease

Phase: Phase 3
Age range: Not provided
Enrollment: 1,380 participants

34 recruiting sites

Updated May 19, 2026

Recruiting

NCT06918808

DB-3Q for Adults With Perianal Fistulizing Crohn’s Disease

A Phase 2 study of DB-3Q injections versus saline placebo in adults with draining perianal fistulas caused by Crohn’s disease.

Perianal Fistula Due to Crohn's Disease

Phase: Phase 2
Age range: 18 Years–75 Years
Enrollment: 36 participants

5 recruiting sites

Updated May 15, 2026

Recruiting

NCT03256240

Kono-S Versus Standard Bowel Reconnection After Crohn's Resection

Comparing two bowel-reconnection techniques for adults having their first resection for Crohn's ileitis or ileocolitis.

Crohn's Disease

Phase: Na
Age range: 18 Years–90 Years
Enrollment: 600 participants

8 recruiting sites

Updated May 14, 2026

Recruiting

NCT05442567

Long-term Vedolizumab Safety Study in Children With Ulcerative Colitis or Crohn’s

Long-term vedolizumab safety study in children with ulcerative colitis or Crohn’s disease who participated in one of two parent studies.

Crohn's Disease · Ulcerative Colitis

Phase: Phase 3
Age range: 2 Years and older
Enrollment: 240 participants

52 recruiting sites

Updated May 7, 2026

Recruiting

NCT04779320

Vedolizumab Maintenance Doses for Children and Teens With Crohn’s Disease

This study compares two maintenance doses of intravenous vedolizumab in children and teens with moderately to severely active Crohn’s disease.

Crohn's Disease (CD)

Phase: Phase 3
Age range: 2 Years–17 Years
Enrollment: 120 participants

80 recruiting sites

Updated May 5, 2026

Recruiting

NCT05660746

Precision versus conventional infliximab dosing for young people with Crohn’s

A study comparing computer-guided precision infliximab dosing with conventional dosing in people ages 6–22 recently diagnosed with Crohn’s disease.

Crohn Disease

Phase: Phase 2, Phase 3
Age range: 6 Years–22 Years
Enrollment: 180 participants

11 recruiting sites

Updated May 5, 2026

Recruiting

NCT07428629

Telehealth Insomnia Therapy for Adults With Ulcerative Colitis

A pilot of telehealth insomnia therapy for adults with ulcerative colitis and insomnia.

Insomnia · Ulcerative Colitis

Phase: Na
Age range: 18 Years and older
Enrollment: 20 participants

1 recruiting site

Updated May 5, 2026

Recruiting

NCT06456593

Obefazimod for Adults With Moderately to Severely Active Crohn’s Disease

A Phase 2 study comparing obefazimod with placebo in adults with moderately to severely active Crohn’s disease.

Moderately to Severely Active Crohn Disease

Phase: Phase 2
Age range: 18 Years–75 Years
Enrollment: 212 participants

149 recruiting sites

Updated Apr 27, 2026

Recruiting

NCT06975722

SAR442970 Dose Study for Adults With Moderate-to-Severe Ulcerative Colitis

A Phase 2b study compares subcutaneous SAR442970 dose regimens with placebo in adults with moderate-to-severe ulcerative colitis.

Ulcerative Colitis

Phase: Phase 2
Age range: 18 Years–75 Years
Enrollment: 99 participants

66 recruiting sites

Updated Apr 23, 2026

Recruiting

NCT07223424

Under-the-Skin vs IV Nivolumab or Pembrolizumab: Patient Preference

A crossover study comparing preference for under-the-skin versus intravenous nivolumab or pembrolizumab in adults with advanced solid tumors.

Cervical Cancer · Colo-rectal Cancer (dMMR/MSI-H CRC) · Esophageal Adenocarcinoma · Esophageal Cancer · Gastric/GEJ · Gastro-Esophageal Adenocarcinoma · Hepatocellular Carcinoma · Melanoma · Non Small Cell Lung Cancer · Renal Cell Carcinoma · Squamous Cell Carcinoma · Ulcerative Colitis

Phase: Phase 2
Age range: 18 Years and older
Enrollment: 880 participants

1 recruiting site

Updated Apr 16, 2026

Recruiting

NCT07524244

Ketogenic or Carnivore Diets for Adults With IBD or Rheumatoid Arthritis

A randomized study of ketogenic and carnivore diets in adults with inflammatory bowel disease or rheumatoid arthritis.

Crohn's Disease (CD) · Rheumatoid Arthritis (RA) · Ulcerative Colitis (UC)

Phase: Na
Age range: 18 Years–64 Years
Enrollment: 160 participants

1 recruiting site

Updated Apr 16, 2026

Recruiting

NCT06693310

Reducing Ulcerative Colitis Treatment During Deep Remission

This study compares continuing versus reducing or stopping therapy in adults with ulcerative colitis in deep remission.

Ulcerative Colitis (UC)

Phase: Na
Age range: 18 Years–75 Years
Enrollment: 200 participants

1 recruiting site

Updated Apr 6, 2026

Recruiting

NCT06774079

Tirzepatide and a Mediterranean Diet for Adults With Mild Crohn’s Disease

A randomized study of tirzepatide plus a Mediterranean diet versus diet alone in adults with mild Crohn’s disease and a BMI of 27 or higher.

Crohn Disease

Phase: Phase 4
Age range: 18 Years and older
Enrollment: 24 participants

1 recruiting site

Updated Mar 30, 2026

Recruiting

NCT06784323

Tailored Anti-Inflammatory Diet Study for Americans With Ulcerative Colitis

A randomized crossover study of a tailored anti-inflammatory diet for Americans ages 16–75 with ulcerative colitis.

Ulcerative Colitis

Phase: Na
Age range: 16 Years–75 Years
Enrollment: 122 participants

1 recruiting site

Updated Mar 30, 2026

Recruiting

NCT06958536

SAR442970 Dose Study for Adults With Moderate-to-Severe Crohn’s Disease

Phase 2 study comparing two SAR442970 dose regimens with placebo in adults ages 18–75 with moderate-to-severe Crohn’s disease.

Crohn's Disease

Phase: Phase 2
Age range: 18 Years–75 Years
Enrollment: 99 participants

66 recruiting sites

Updated Mar 27, 2026

Recruiting

NCT07113522

Phase 2 Study of MT-501 and MT-201 for Active Crohn’s Disease or Ulcerative Colitis

A Phase 2 study of MT-501 and MT-201 in adults with moderately to severely active Crohn’s disease or ulcerative colitis.

Crohn's Disease · Inflammatory Bowel Disease (IBD) · Ulcerative Colitis (UC)

Phase: Phase 2
Age range: 18 Years–80 Years
Enrollment: 140 participants

66 recruiting sites

Updated Mar 12, 2026

Recruiting

NCT04373473

Oral Fecal Microbiota Capsules to Prevent Ulcerative Colitis Relapse

Testing oral PRIM-DJ2727 fecal microbiota capsules versus placebo in adults whose ulcerative colitis is in remission.

Adults With Ulcerative Colitis

Phase: Phase 2
Age range: 18 Years and older
Enrollment: 58 participants

1 recruiting site

Updated Mar 9, 2026

Recruiting

NCT03615690

Fasting-Mimicking Diet Study for Mild to Moderate Ulcerative Colitis

A randomized study of a fasting-mimicking diet versus regular diet in adults with mild to moderate ulcerative colitis.

Diet Modification · Inflammatory Bowel Disease · Ulcerative Colitis

Phase: Na
Age range: 18 Years–70 Years
Enrollment: 75 participants

1 recruiting site

Updated Feb 27, 2026

Recruiting

NCT04401605

Fermented Food-Supplemented Diet Study for Adults With Ulcerative Colitis

A randomized study of a fermented food-supplemented diet in adults with symptomatic ulcerative colitis and elevated fecal calprotectin.

Diet Modification · Inflammatory Bowel Diseases · Ulcerative Colitis

Phase: Na
Age range: 18 Years and older
Enrollment: 21 participants

1 recruiting site

Updated Feb 27, 2026

Recruiting

NCT06495658

Prebiotic Supplement Timing in Adults With Active Ulcerative Colitis

A randomized study of daily prebiotic supplementation in adults with active, biopsy-confirmed ulcerative colitis.

Crohn Disease · Ulcerative Colitis

Phase: Na
Age range: 18 Years–85 Years
Enrollment: 70 participants

1 recruiting site

Updated Feb 27, 2026